DepressionTypes An Overview of Persistent Depressive Disorder (Dysthymia) ByNancy SchimelpfeningNancy SchimelpfeningNancy Schimelpfening, MS is the administrator for the non-profit depression support group Depression Sanctuary. Nancy has a lifetime of experience with depression, experiencing firsthand how devastating this illness can be.Learn about our editorial processUpdated on May 23, 2022Medically reviewed Verywell Mind articles are reviewed by board-certified physicians and mental healthcare professionals. Medical Reviewers confirm the content is thorough and accurate, reflecting the latest evidence-based research. Content is reviewed before publication and upon substantial updates. Learn more. by Daniel B. Block, MDMedically reviewed byDaniel B. Block, MDLinkedInTwitterDaniel B. Block, MD, is an award-winning, board-certified psychiatrist who operates a private practice in Pennsylvania.Learn about our Medical Review BoardJGI / Jamie Gril / Getty Images Table of Contents View All Table of ContentsWhat Is Persistent Depressive Disorder (Dysthymia)?Symptoms of PDD (Dysthymia)Causes of PDD (Dysthymia)Diagnosis of PDD (Dysthymia)Treatment for PDD (Dysthymia)Coping With Persistent Depressive Disorder (Dysthymia) What Is Persistent Depressive Disorder (Dysthymia)? Persistent depressive disorder (PDD), formerly known as dysthymia, is a fairly new diagnosis that is characterized by chronic depression. The latest edition of the "Diagnostic and Statistical Manual of Mental Disorders" (DSM-5) consolidated dysthymia and chronic major depressive disorder under the umbrella of persistent depressive disorder, which includes any chronic depression running on a spectrum from mild to severe. These diagnostic changes were made to reflect the fact that there is no scientifically meaningful distinction between chronic major depressive disorder and what was previously known in the DSM-IV as dysthymic disorder.The word dysthymia comes from the Greek roots dys, meaning "ill" or "bad," and thymia, meaning "mind" or "emotions." The terms dysthymia and dysthymic disorder referred to a mild, chronic state of depression. Symptoms of PDD (Dysthymia) The symptoms of persistent depressive disorder are very similar to major depressive disorder. However, these symptoms are chronic, meaning that people have these depressive symptoms most days for a period of at least two years for adults and one year for children and teens. The symptoms include: Decreased productivityFeelings of guiltFeelings of helplessnessFeelings of sadnessHopelessness or feeling stuck in a rutIncreases or decreases in appetiteIrritabilityLack of energy or fatigueLoss of interest and pleasure in daily activitiesLow moodPoor self-esteemSleep difficultiesSocial withdrawalTrouble concentrating While people with major depressive disorder may have days or periods where they feel better, those with dysthymia have depressive symptoms almost all the time for a long time. PDD may have an early onset, with symptoms first appearing during the child, teen, or young adult years. In kids, the primary symptoms are depressed mood and irritability. Double DepressionA person with mild depression meeting the diagnostic criteria for persistent depressive disorder can also experience major depressive episodes. When the major depressive episode has ended, however, there is a return to the previous state of chronic depression. This co-occurrence of PDD and major depressive disorder is sometimes referred to as double depression. Causes of PDD (Dysthymia) Like other forms of depression, the exact cause of PDD is not known, but there are a number of factors that are believed to play a role, including: Brain chemistry: The balance of neurotransmitters in the brain can play a role in the onset of depression. Some environmental factors, such as prolonged stress, can actually alter these brain chemicals. Antidepressants work by altering these neurotransmitters in order to improve mood.Environmental factors:Situational variables such as stress, loss, grief, major life changes, and trauma can also cause depression.Genetics: Research suggests that having close family members with a history of depression doubles a person's risk of also developing depression. In many cases, these factors interact to increase the risk of developing depression. Factors That Increase the Risk of Depression Diagnosis of PDD (Dysthymia) There was and still is no laboratory test for diagnosing dysthymia or any other form of depression. If you are experiencing symptoms of depression, your doctor will evaluate your symptoms and medical history. You will be asked questions about the nature, severity, and duration of your symptoms. Your doctor may conduct testing such as a physical and blood work to rule out any medical illnesses that might be causing your symptoms. To receive a diagnosis of PDD, your doctor must determine that your symptoms could not be better accounted for by drug or alcohol use, a medical condition, or another psychological disorder. In order to be diagnosed with persistent depressive disorder, your doctor will check to see if your symptoms meet the diagnostic criteria outlined in the DSM-5, which includes duration requirements. For adults, symptoms of depression must be experienced more often than not for at least two years prior. For children, the requirement was lowered to one year. Lastly, the symptoms must result in significant distress or impairment of normal functioning. PDD is sometimes difficult to diagnose because symptoms are so long-lasting that many people begin to believe that their symptoms are simply a part of their personality or "who they are" rather than a result of a treatable condition. Or they may attribute these feelings to just being stuck in a rut rather than as symptoms of a mental health condition. According to the American Psychiatric Association, between 0.5% and 1.5% of U.S. adults experiencing persistent depressive disorder each year. A 2017 study suggested that the lifetime prevalence for PDD with major depressive episodes was 15.2%. Treatment for PDD (Dysthymia) The treatments for persistent depressive disorder are similar to other treatments of depression. Generally, a combination of psychotherapy and medications is the most effective. Talk Therapy Psychotherapy may involve a range of different techniques, but two that are often used are cognitive behavioral therapy (CBT) and interpersonal therapy (IPT). CBT: This type of therapy focuses on learning to identify and change the underlying negative thought patterns that often contribute to feelings of depression.IPT: This therapy is similar to CBT but focuses on identifying problems in relationships and communication and then finding ways to make improvements in how you relate to and interact with others.The Best Online Help Resources for Depression Medication There are a number of different types of antidepressants that may be prescribed to treat PDD, including: Selective serotonin reuptake inhibitors (SSRIs): These medications include sertraline Zoloft (sertraline) and Prozac (fluoxetine). SSRIs work by increasing serotonin levels in the brain, which can help improve and regulate mood.Serotonin and norepinephrine reuptake inhibitors (SNRIs): These medications include Cymbalta (duloxetine) and Pristiq (desvenlafaxine). SNRIs work by increasing the amount of serotonin and norepinephrine in the brain.St. John's Wort, which has been reported to be helpful in cases of mild to moderate depression, is sometimes used as a self-help remedy. While St. John's Wort and other natural treatment options appear to work for some people with depression, it's important that you never take any supplement without first talking to your doctor.When combined with antidepressants, this herbal remedy may lead to a dangerous complication known as serotonin syndrome.Drugs That Increase the Risk of Serotonin Syndrome Coping With Persistent Depressive Disorder (Dysthymia) There are a number of different things that people can do to help cope with persistent depression. Because this type of depression is chronic, incorporating lifestyle changes and self-care with your medical treatments can be helpful. Some things that you can do that will complement therapy and medication: Avoid alcohol and other substances.Createdaily routines that help structure your day.Eat a healthy diet.Establish a consistent sleep schedule.Get regular exercise several times each week.Leave the house and make plans with friends.Practice stress management techniques such as deep breathing and meditation. It can be challenging to do many of these things when you are feeling depressed. While it may be a struggle, remember that you don't need to do it all perfectly. Even small changes can make a difference in your mood and mindset. For example, you might start out by making small goals and then gradually build on these over time. If you or a loved one are struggling with depression, contact the Substance Abuse and Mental Health Services Administration (SAMHSA) National Helpline at 1-800-662-4357 for information on support and treatment facilities in your area.For more mental health resources, see our National Helpline Database.Tips for Living With Depression A Word From Verywell Even very mild symptoms of depression can disrupt your ability to function and enjoy life, particularly when these symptoms are long-lasting. Fortunately, there are effective treatments available for persistent depressive disorder that can make a major difference in your health and well-being. Talk to your doctor about how you are feeling to explore the treatment options that are right for you. What Is Mild Depression? 3 Sources Verywell Mind uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read our editorial process to learn more about how we fact-check and keep our content accurate, reliable, and trustworthy.Parker G, Malhi GS. Persistent depression: Should such a DSM-5 diagnostic category persist?The Canadian Journal of Psychiatry. 2019;64(3):177-9. doi:10.1177/0706743718814429Vandeleur CL, Fassassi S, Castelao E, et al. Prevalence and correlates of DSM-5 major depressive and related disorders in the community. Psychiatry Res. 2017;250:50-58. doi:10.1016/j.psychres.2017.01.060Xie Y, Wu Z, Sun L, et al. The effects and mechanisms of exercise on the treatment of depression. Front Psychiatry. 2021;12:705559. doi:10.3389/fpsyt.2021.705559 Additional ReadingHighlights of Change From DSM-IV-TR to DSM-5. American Psychiatric Association. American Psychiatric Publishing. Published 2013.American Psychiatric Association. Diagnostic and statistical manual of mental disorders (5th ed.). Washington, DC: 2013.Monroe SM, Slavich GM, Gotlib IH. Life stress and family history for depression: the moderating role of past depressive episodes. J Psychiatr Res. 2014;49:90-95. doi:10.1016/j.jpsychires.2013.11.005By Nancy Schimelpfening Nancy Schimelpfening, MS is the administrator for the non-profit depression support group Depression Sanctuary. Nancy has a lifetime of experience with depression, experiencing firsthand how devastating this illness can be. See Our Editorial ProcessMeet Our Review Board Share FeedbackWas this page helpful?Thanks for your feedback!What is your feedback? Other Helpful Report an Error Speak to a Therapist for Depression Advertiser Disclosure × The offers that appear in this table are from partnerships from which Verywell Mind receives compensation.